Kruppel-Like Factors 4 and 5: Unity in Diversity
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چکیده
منابع مشابه
Krüppel-Like Factors 4 and 5: Unity in Diversity
Krüppel-like factors (Klf) 4 and 5 belong to a family of zinc finger-containing transcription factors that share homology with the Drosophila gene Krüppel. They regulate proliferation and differentiation of a wide variety of cells and have been linked to tumorigenesis. Their most striking role so far has turned out to be their ability to reprogram/ maintain embryonic stem cell fate. In this rev...
متن کاملKLF 5 ( Kruppel - like factor 5 ( intestinal ) )
KLF5 is a transcription factor. Many KLF5 target genes, such as PDGFa, PPARg, NFkB, cyclinD1, KLF4, and TCR, have been identified in different cell models. KLF5 regulates cell proliferation, cell cycle, apoptosis, and differentiation. KLF5 is an important transcription factor for cardiovascular remodeling and tumor angiogenesis. KLF5 is essential for mouse embryo development. Additionally, KLF5...
متن کاملKLF 4 ( Kruppel - like factor 4 ( gut ) )
A full-length mouse cDNA clone encoding KLF4 was initially isolated from a NIH3T3 cDNA library by reduced stringency screening with a DNA probe containing the zinc finger region of an immediate early gene product, Zif268 or Egr1. A distinct feature of the KLF4 gene is the highly GC-rich nature of the sequence near its 5'-end. Thus, the G+C content of the 1000 nt 5'-flanking region is 67% and th...
متن کاملKruppel - like factor 4 ( KLF 4 ) and cancer literatures
Kruppel-like factor 4 (KLF4) is a member of the KLF family of transcription factors and regulates proliferation, differentiation, apoptosis and somatic cell reprogramming. KLF4 is also a tumor suppressor in certain cancers. KLF4 can be an indicator of stem-like capacity in embryonic stem cells (ESCs) and mesenchymal stem cells (MSCs), etc. The KLF4 gene is conserved in chimpanzee, Rhesus monkey...
متن کاملSite-specific microRNA-92a regulation of Kruppel-like factors 4 and 2 in atherosusceptible endothelium.
OBJECTIVE Endothelial transcription factors Krüppel-like factor 4 (KLF4) and KLF2 are implicated in protection against atherogenesis. Steady-state microRNA (miR) regulation of KLFs in vivo is accessible by screening region-specific endothelial miRs and their targets. METHODS AND RESULTS A subset of differentially expressed endothelial miRs was identified in atherosusceptible versus protected ...
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ژورنال
عنوان ژورنال: Current Genomics
سال: 2009
ISSN: 1389-2029
DOI: 10.2174/138920209789503932